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  • Title: Effect of actinomycin D and neoarsphenamine on tumor control and skin tolerance in the rat.
    Author: Moulder JE, Lo PS, Fischer JJ.
    Journal: Cancer Treat Rep; 1978 May; 62(5):713-9. PubMed ID: 148967.
    Abstract:
    Actinomycin D and neoarsphenamine were tested for their ability to produce therapeutically favorable radiosensitization in the WAG/Rij rat. Acute and late skin reactions and control of the BA1112 rhabdomyosarcoma were examined in drug-treated and untreated animals irradiated in single- and five-fraction schedules. Actinomycin D was found to protect skin and tumors when added 15 minutes before irradiation. Actinomycin D added 2 hours before irradiation in a five-fraction trial produced slight tumor sensitization accompanied by slight skin protection. Neoarsphenamine produced significant tumor sensitization without skin sensitization in one of the single-fraction trials, but had no effect in the five-fraction trials.
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