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  • Title: Photosensitivity induced by quinidine sulfate: experimental reproduction of skin lesions.
    Author: Schürer NY, Hölzle E, Plewig G, Lehmann P.
    Journal: Photodermatol Photoimmunol Photomed; 1992 Apr; 9(2):78-82. PubMed ID: 1489721.
    Abstract:
    A case of quinidine sulfate-induced photodermatitis is reported. The photosensitive reaction to quinidine sulfate was reproducible in the photopatch test and after oral intake plus ultraviolet A (UVA) irradiation. Eczematous dermatitis was provoked after intradermal injection of in vitro UVA-irradiated quinidine sulfate only in the presence of patient's serum. The clinical picture and histology suggest an allergic reaction. The photobinding of quinidine sulfate to a potential carrier protein in skin or serum seems to be of crucial importance for this type of photodermatitis. Quinidine sulfate is frequently used as an antiarrhythmic drug. Its potential as a photosensitizer should always be considered.
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