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  • Title: [Cytogenetic subtyping of 139 uterine leiomyoma].
    Author: Stern C, Deichert U, Thode B, Bartnitzke S, Bullerdiek J.
    Journal: Geburtshilfe Frauenheilkd; 1992 Dec; 52(12):767-72. PubMed ID: 1490556.
    Abstract:
    A cytogenetic study of 139 uterine leiomyomas of 70 patients is presented. 26 of the tumours failed to grow, 87 showed an apparently normal karyotype and 26 tumours were characterised by clonal aberrations. In 5 tumours, a numerical change was the only abnormality, including 2 tumours with a trisomy 12. 5 myomas showed an interstitial deletion of the long arm of chromosome 7. The largest group were 9 tumours with an aberration involving chromosome 12 in the band of 14-15. 2 myomas showed a t(12; 14) as the only abnormality, in 4 tumours very complex rearrangements with up to 12 breakpoints were observed. In the last group 7 myomas with other clonal aberrations involving 11 different chromosomes were found.
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