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  • Title: [Cyclosporin in a bioadhesive formulation in the therapy of oral erosive lichen planus. A clinico-experimental evaluation].
    Author: Gombos F, Cappello B, Gaeta GM, La Rotonda MI, Serpico R, Miro A.
    Journal: Minerva Stomatol; 1992 Sep; 41(9):385-9. PubMed ID: 1491655.
    Abstract:
    This study illustrates the possible topical therapy of OLP with cyclosporine A under bioadhesive gel formula. The treatment was carried out on 6 patients for 8 weeks in much lower (48 mg/day) than those used by other authors. The novelty of this study lies in the use of a bioadhesive formula with carbosymethylcellulose which allows CsA to remain on oral mucosa for about two hours. The remarkable results have shown a reduction ranging from 50 to 80% of oral lesions, thus proposing its specific use in all the forms resisting usual therapy.
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