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  • Title: Mating-type gene switching in Saccharomyces cerevisiae.
    Author: Haber JE.
    Journal: Trends Genet; 1992 Dec; 8(12):446-52. PubMed ID: 1492369.
    Abstract:
    The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.
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