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  • Title: [Status of the monooxygenase enzyme system in rat and rabbit organs in sugar diabetes and upon insulin administration].
    Author: Krakovskiĭ ME, Ashirmetov AKh.
    Journal: Vopr Med Khim; 1992; 38(5):59-62. PubMed ID: 1492403.
    Abstract:
    Content of cytochromes P450 and b5, activities of amidopyrine-N-demethylase, alanine- and p-nitrophenol hydroxylases, NADPH-cytochrome c reductase were studied in the liver, kidney, small intestine and lung tissues of rats and rabbits in insulin-dependent hypoglycemia and alloxan diabetes. The diabetes and hypoglycemia caused dissimilar alterations in activity of alanine- and p-nitrophenol hydroxylases, thus indicating their dependence on blood sugar levels. The activity of monooxygenase enzymes studied was altered similarly in rabbit liver and other tissues, while the enzymatic activity was distinctly differentiated in rat tissues. Specific properties of cytochromes P450 isozyme spectra appear to be responsible for these alterations detected.
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