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  • Title: I-protein, a new regulatory protein from vertebrate skeletal muscle. III. Function.
    Author: Maruyama K, Kunitomo S, Kimura S, Ohashi K.
    Journal: J Biochem; 1977 Jan; 81(1):243-7. PubMed ID: 14932.
    Abstract:
    I-protein inhibited theMg-activated ATPase [EC 3.6.1.3] activity of actinomyosin by approximately 50% at low ionic strength. Concomitantly, the onset of superprecipitation was retarded. I-protein was found to bind to myosin, but not to F-actin. The inhibitory action of I-protein occurred only in the absence of Ca ions in the troponintropomyosin-actin myosin system. Addition of Ca ions abolished the effect. Thus, it is very likely that I-protein prevents unnecessary hydrolysis of ATP in the relaxed state of muscle.
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