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  • Title: [Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin].
    Author: Kudriashov BA, Liapina LA, Ul'ianov AM.
    Journal: Vopr Med Khim; 1978; 24(2):255-60. PubMed ID: 149422.
    Abstract:
    Intravenous administration of plasmin as distinct from thrombin inhibited or did not provide a secretion of endogenous heparin into circulation. In these conditions non-enzymatic fibrinolysis was not observed both in fraction of euglobulins and in fibrinogen-heparin complex, isolated from euglobulins, due to insufficiency of heparin. Exogenous heparin, injected into circulation or added to corresponding fractions, enabled to produce the active heparin complexes. About 70% of total fibrinolytic activity was due to fibrinogen-heparin complex in euglobulin fraction of blood plasma, isolated from blood of animals intravenously administered with thrombin.
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