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  • Title: [Role of membrane-bound calcium in changes in the ATPase activity, permeability and structural state of human erythrocyte membranes].
    Author: Orlov SN, Shevchenko AS, Postnov IuV.
    Journal: Biull Eksp Biol Med; 1978 Jun; 85(6):682-5. PubMed ID: 149575.
    Abstract:
    A study was conducted on the reconstituted erythrocytes obtained by the method of fast reversible hemolysis. The concentration of free Ca2+ ions in the reconstituted erythrocytes was supported by Ca-EGTA and Ca-nitrate buffers. Oubain-uninhibited ATPase component with a high affinity for Ca2+ (K0.5=4 micron) and alteration of passive and active K+-permeability in the region of free Ca2+ concentration up to 10 micron could be determined only when the content of membrane-bound Ca+ varied. Depletion of the inner side of the membrane of reconstituted erythrocyte is accompanied by alteration of hydrophobic character of the hydrocarbon region of the membrane. It is suggested that Ca+-induced alterations in the structure of the erythrocyte membrane may be a direct cause of the alterations in ATPase activity with a high Ca2+ affinity and permeability for univalent cations.
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