These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Sensory responses of neurons in the medial septal area to modulation of the theta-activity by alpha2-adrenergic receptor agonist clonidine].
    Author: Kichigina VF, Kutyreva ES, Sudnitsyn VV.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 2003; 53(6):754-65. PubMed ID: 14959490.
    Abstract:
    It was shown by us earlier that bilateral intracerebroventricular injection of alpha2-adrenoreceptor agonist clonidine produced a dose-dependent effect on theta oscillations in the septohippocampal system of awake rabbits. A relatively low dose of clonidine (0.5 microgram) attenuated and a high dose (5 micrograms) significantly enhanced the rhythmic activity. It was suggested that the effect of the low dose of clonidine is mediated by presynaptic alpha2-adrenoreceptors were as postsynaptic alpha2-adrenoreceptors. In this article sensory neuronal responses in the medial septal area (MS) were analyzed against the background of the theta activity modulation by different clonidine doses. Different effects of the low and high doses of the agonist were revealed. The low dose of clonidine (0.5 microgram in 5 microliters into each lateral ventricle) which produced a decrease in the theta activity resulted in attenuation of excitation and enhancement of inhibition, i.e., the number of activating effects significantly decreased and inhibitory responses were more frequent and distinct. The high dose of clonidine (5 micrograms in 5 microliters) which produced a sharp increase in the theta activity led to a significant decrease in the reactions of the MS cells to sensory stimuli (from 76.8% in the control to 45% under clonidine) independently on the initial reaction character. Persisted excitatory and inhibitory responses became less distinct than the initial ones except single excitatory reactions. The results suggest that alpha2-adrenoreceptors are involved in the control of the sensory reactivity of MS neurons. A sharp decrease in neuronal reactivity during stable rhythmical oscillations developing under the influence of high dose of clonidine confirm the role of the theta rhythm in the septohippocampal system as an active filter in information selection and registration.
    [Abstract] [Full Text] [Related] [New Search]