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  • Title: Exposure to postnatal depression predicts elevated cortisol in adolescent offspring.
    Author: Halligan SL, Herbert J, Goodyer IM, Murray L.
    Journal: Biol Psychiatry; 2004 Feb 15; 55(4):376-81. PubMed ID: 14960290.
    Abstract:
    BACKGROUND: Animal research shows that early adverse experience results in altered glucocorticoid levels in adulthood, either raised basal levels or accentuated responses to stress. If a similar phenomenon operates in humans, this suggests a biological mechanism whereby early adversity might transmit risk for major depression, glucocorticoid elevations being associated with the development of this disorder. METHODS: We measured salivary cortisol at 8:00 am and 8:00 pm over 10 days in 13-year-old adolescents who had (n = 48) or had not (n = 39) been exposed to postnatal maternal depression. RESULTS: Maternal postnatal depression was associated with higher, more variable morning cortisol in offspring, a pattern previously found to predict major depression. CONCLUSIONS: Early adverse experiences might alter later steroid levels in humans. Because maternal depression confers added risk for depression to children, these alterations might provide a link between early events and later psychopathology.
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