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  • Title: SVM based method for predicting HLA-DRB1*0401 binding peptides in an antigen sequence.
    Author: Bhasin M, Raghava GP.
    Journal: Bioinformatics; 2004 Feb 12; 20(3):421-3. PubMed ID: 14960470.
    Abstract:
    Prediction of peptides binding with MHC class II allele HLA-DRB1(*)0401 can effectively reduce the number of experiments required for identifying helper T cell epitopes. This paper describes support vector machine (SVM) based method developed for identifying HLA-DRB1(*)0401 binding peptides in an antigenic sequence. SVM was trained and tested on large and clean data set consisting of 567 binders and equal number of non-binders. The accuracy of the method was 86% when evaluated through 5-fold cross-validation technique.
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