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  • Title: Phosphomonoesters predict early mortality in porcine hemorrhagic shock.
    Author: Taylor JH, Beilman GJ, Conroy MJ, Mulier KE, Hammer BE.
    Journal: J Trauma; 2004 Feb; 56(2):251-8. PubMed ID: 14960964.
    Abstract:
    BACKGROUND: Hemodynamic, laboratory, and tissue energetics were measured in a porcine model of hemorrhagic shock to evaluate variables as predictors of early mortality from shock. We hypothesized that elevated phosphomonoesters would predict early mortality in hemorrhagic shock. METHODS: Pigs (n = 36) were subjected to 35% hemorrhage for 90 minutes in a 1.5-T nuclear magnetic resonance (NMR) magnet. Measurements included base deficit (BD); lactate; oxygen consumption/delivery; near-infrared spectroscopy of liver, stomach, and skeletal muscle tissue oxyhemoglobin saturation; and NMR spectroscopic measurements of high-energy phosphates of liver and skeletal muscle. Variables were compared between nonsurvivors and survivors to resuscitation after 90-minute measurements. RESULTS: Ninety-minute mortality was 25%. Muscle phosphomonoesters (PMEs) and oxygen consumption differed significantly between survivors and nonsurvivors at baseline. Regression analysis identified baseline muscle PME levels, baseline BD, and 30-minute BD as early predictors of mortality before resuscitation (r2 = 0.304). CONCLUSION: Baseline elevation in muscle PME levels predicts mortality in an animal model of severe hemorrhagic shock.
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