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  • Title: A convergent synthesis of the macrocyclic core of cytotrienins: application of RCM for macrocyclization.
    Author: Evano G, Schaus JV, Panek JS.
    Journal: Org Lett; 2004 Feb 19; 6(4):525-8. PubMed ID: 14961614.
    Abstract:
    [reaction: see text] The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A-D, potent apoptosis-inducing agents, is described. Synthetic highlights include the construction of the aniline bond using a copper-mediated amidation and the use of a ring-closing metathesis (RCM) reaction to efficiently install the (E,E,E)-triene and simultaneously construct the macrocyclic lactam.
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