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  • Title: Event-related potentials elicited by non-target tones in an auditory oddball paradigm in schizophrenia.
    Author: Higashima M, Nagasawa T, Kawasaki Y, Oka T, Sakai N, Tsukada T, Komai Y, Koshino Y.
    Journal: Int J Psychophysiol; 2004 Feb; 51(3):189-200. PubMed ID: 14962570.
    Abstract:
    It has been reported that in event-related potentials (ERPs) elicited by non-target tones in oddball paradigms, the superimposition of a negative component on the descending slope of N100 depends on subjects' attention to the task. We tested the possibility that this attention-related change is abnormal for patients with schizophrenia. ERPs induced by non-target, frequent tones were measured for 52 patients and 31 healthy controls under two oddball conditions: a passive condition where the subjects were told to disregard the tones, and an active condition where they were instructed to respond to infrequent tones. For both groups, a negative component was superimposed from the descending slope of N100 to the end of P150 (latency, 120-200 ms) for the active condition. The peak latency of this attention-related negative component was longer for the patients than for the controls, while the amplitude showed no group difference. In addition, the active P150 for the patients was more enlarged than that for the controls. Furthermore, the active P150 amplitude for the patients correlated positively with the score for the negative symptom factor of the Positive and Negative Syndrome Scale. These findings suggest that the enlargement of non-target P150 observed in conjunction with the latency prolongation of the attention-related negative component may be a biological marker for the severity of the negative symptoms in schizophrenia.
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