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  • Title: [Mechanisms of nitric oxide activity in cardiovascular system as a basis of pathogenetic therapy of related diseases].
    Author: Moĭbenko OO, Sahach VF, Tkachenko MM, Korkushko OV, Bezrukov VV, Kul'chyts'kyĭ OK, Stefanov OV, Solovĭov AI, Mala LT, Frol'kis VV.
    Journal: Fiziol Zh (1994); 2004; 50(1):11-30. PubMed ID: 14965048.
    Abstract:
    General characteristics and mechanisms of effects of nitric oxide (NO) and its role in the development of pathology are reviewed. Presented are the data about NO participation in the regulation of circulation and cardiovascular system; NO-dependent mechanism of regulation of cardiovascular reactivity against the background of dysfunction of endothelium; cGMP-independent mechanism of NO effect upon Ca homeostasis and the sensitivity of myofibrils of smooth muscle cells to Ca ions; pharmacological correction of disturbances of NO metabolism and related endothelial dysfunction; role of age changes of the endothelial function in the development of cardiovascular pathology.
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