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  • Title: Clinical evaluation of abdominal multiorgan transplantation.
    Author: Yu LX, Liu XY, Xu J, Deng WF, Ye GR, Fu SJ, Du CF, Ma JJ.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 Feb; 24(2):148-51. PubMed ID: 14965812.
    Abstract:
    OBJECTIVE: To evaluate the clinical effect of abdominal multiorgan transplantation in patients with multiorgan failure. METHODS: Simultaneous kidney-pancreas transplantation (SKPT) with enteric drainage of pancreatic exocrine secretions was performed in 2 patients with type 1 diabetes and end-stage renal disease. A combined liver-kidney transplantation (CLKT) was done in a 66-year-old patient with alcoholic liver cirrhosis and uremia. Simultaneous orthotopic liver and heterotopic pancreas-duodenum transplantation (SLPT) was performed in a patient with hepatitis B, hepatocirrhosis, hepatic cellular cancer, and type 1 diabetes. RESULTS: The function of kidney grafts became normal 5 days postoperatively and insulin-independent after treatment with low dose insulin for 10 days in the 2 SKPT patients. For the CLKT patient, both transplanted organs rapidly achieved normal functions after operation but suffered-acute liver graft rejection on postoperation day 10 and the rejection was controlled after methylprednisolone pulse therapy. In the SLPT patient, insulin was withdrawn 5 days after operation, liver allograft function recovered well. All the patients are alive with stable allograft function after following-up for 29, 26, 9 and 6 months, respectively. CONCLUSIONS: Abdominal multi organ transplantation was effective therapy to patients with multiple organ failure. SLPT can reduce acute pancreas rejection and promote the recovery of liver allograft.
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