These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Establishment and drug-resistance gene expression of cisplatin-resistant cell line Tca8113/CDDP].
    Author: Zhou XJ, Li Q, Chen WT.
    Journal: Shanghai Kou Qiang Yi Xue; 2003 Dec; 12(6):432-5. PubMed ID: 14966583.
    Abstract:
    OBJECTIVE: To establish a CDDP-resistant cell line from human tongue squamous cell carcinoma cell line Tca8113 and to compare the drug-resistance gene expression between them. METHODS: The concentration of CDDP added to Tca8113 cells was increased stepwise to induce the CDDP-resistance. The index of drug-resistance was estimated by MTT assay. The expression of MDR-1, MRP, GST-pi and Bcl-2 was measured by RT-PCR optical density OD. RESULTS: The CDDP-resistant cell line, Tca8113/CDDP was established, whose drug-resistance index was 9.2. The expression of MDR-1, MRP, cyclin D1 and Bcl-2 increased respectively. CONCLUSION: The expression of drug-resistance gene in Tca8113/CDDP was significantly higher than that in Tca8113.
    [Abstract] [Full Text] [Related] [New Search]