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  • Title: Lack of interaction of spironolactone with ouabain guinea pig isolated heart muscle preparations.
    Author: Fricke U.
    Journal: Eur J Pharmacol; 1978 Jun 15; 49(4):363-71. PubMed ID: 149671.
    Abstract:
    The effect of spironolactone on ouabain action was studied in experiments on guinea pig isolated heart muscle preparations. There was no effect of spironolactone on the ouabain-induced positive inotropic or toxic effects in isolated papillary muscles. This was accompanied by a lack of spironolactone effect on myocardial ouabain uptake. Only rather high spironolactone concentrations (1 X 10(-4) M) led to a reduced cardiac ouabain uptake (about 10%). The subcellular distribution pattern of ouabain, however, remained unchanged under these conditions. Studies on ouabain binding to a cardiac NaK-ATPase supported the conclusion that a direct interaction of spironolactone and cardiac glycosides at the myocardium could be ruled out.
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