These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier.
    Author: Chauvierre C, Marden MC, Vauthier C, Labarre D, Couvreur P, Leclerc L.
    Journal: Biomaterials; 2004 Jul; 25(15):3081-6. PubMed ID: 14967542.
    Abstract:
    A new generation of drug delivery systems based on heparin-poly(isobutylcyanoacrylate) copolymers has been developed to carry hemoglobin. These copolymers spontaneously form, in water, nanoparticles with a ciliated surface of heparin. These nanoparticles maintain the heparin antithrombotic properties and inhibit complement activation. One ml of nanoparticle suspension can be loaded with up to 2.1mg of hemoglobin, which preserves its ligand binding capacity. This work constitutes the first demonstration of hemoglobin loaded on nanoparticle surface, rather than being encapsulated. With a size of 100 nm, these drug delivery systems make suitable tools in the treatment of thrombosis oxygen deprived pathologies.
    [Abstract] [Full Text] [Related] [New Search]