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  • Title: Genetic Analysis Workshop II: results of incorporating a linkage disequilibrium parameter.
    Author: Goldgar DE, Fain PR.
    Journal: Genet Epidemiol; 1984; 1(2):179-82. PubMed ID: 14971367.
    Abstract:
    The corporation of a linkage disequilibrium parameter, delta, into linkage analysis is illustrated for data from Genetic Analysis Workshop II. Points from a joint likelihood surface are calculated and displayed on a recombination fraction-linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.
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