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  • Title: Genetic Analysis Workshop II: multiple-locus segregation analysis incorporating linkage markers.
    Author: Risch N.
    Journal: Genet Epidemiol; 1984; 1(2):207-11. PubMed ID: 14971378.
    Abstract:
    The workshop data were examined using a newly developed methodology (MILINK, Risch, 1984) for combined segregation, linkage, and association analysis of a complex disease trait in pedigree data. Results from problems two and three suggest that the method is powerful both for determining mode of disease inheritance and for resolution of linkage disequilibrium versus pleiotrophy (with epistasis) of marker alleles.
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