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  • Title: [Study of serum kinetics of vancomycin during the "antibiotic-lock" technique].
    Author: Elian JC, Frappaz D, Ros A, Gay JP, Guichard D, Dorche G, Aubert G, Bouteille M, Ollagnier M, Freycon F.
    Journal: Arch Fr Pediatr; 1992 Apr; 49(4):357-60. PubMed ID: 1497425.
    Abstract:
    The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
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