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  • Title: Effect on ribonucleotide reductase of novel lipophilic iron chelators: the desferri-exochelins.
    Author: Hodges YK, Antholine WE, Horwitz LD.
    Journal: Biochem Biophys Res Commun; 2004 Mar 12; 315(3):595-8. PubMed ID: 14975742.
    Abstract:
    Desferri-exochelins are siderophores secreted by Mycobacterium tuberculosis that are both lipid- and water-soluble and have a high binding affinity for iron. Desferri-exochelin 772SM inhibits DNA replication and ribonucleotide reductase activity at 10-fold less concentration than the lipid-insoluble iron chelator deferoxamine, which is currently in clinical use. Neither chelator can extract iron directly from ribonucleotide reductase. However, because of its lipid-solubility and high binding affinity, desferri-exochelin is able to enter cells rapidly and access intracellular iron, while deferoxamine has limited capacity to cross the cell membrane.
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