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  • Title: [Adjuvant chemotherapy in non-small cell lung cancer].
    Author: Taillade L, Soria JC, André F, Grunenwald D, Dunant A, Pignon JP, Le Chevalier T.
    Journal: Bull Cancer; 2004 Jan; 91(1):63-7. PubMed ID: 14975806.
    Abstract:
    Lung cancer is the leading cause of cancer death in France. Nearly 80% of lung tumors are non-small cell lung cancers (NSCLC). Surgery is the best curative approach, but it only concerns 30% of NSCLC, since the diagnosis is frequently made in patients with locally advanced or metastatic disease. Even when surgery is performed relapse occurs in up to 50% of patients. Several adjuvant trials have been led in the late 90's after an individual data-based meta-analysis suggested a 5% survival benefit at 5 years. Among those, the IALT study, with 1 867 patients included, confirms the benefit of post-operative chemotherapy in resected NSCLC. In this article, the current status of adjuvant chemotherapy is reviewed, and future prospects are discussed.
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