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  • Title: Synthesis and inhibitory effects of 1,2,4-triazole derivatives on platelet aggregation.
    Author: Lagorce JF, Moulard T, Raby C.
    Journal: Arzneimittelforschung; 1992 Mar; 42(3):314-8. PubMed ID: 1497691.
    Abstract:
    Various derivatives of triazole substituted in the 2-position were prepared, and their activity on platelet aggregation tested. Compounds 4 and 14 had the most powerful action. These agents were thought to inhibit platelet aggregation via an inhibition of the cyclo-oxygenase-peroxidase complex (PGS complex), preventing synthesis of prostaglandins.
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