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  • Title: Characterization of the Syrian hamster c-Ha-ras gene and intron-D-exon transcript.
    Author: Ebert R, Wiseman RW, Barrett JC, Reiss E, Rollich G, Schiffmann D.
    Journal: Mol Carcinog; 1992; 5(4):254-8. PubMed ID: 1497801.
    Abstract:
    The coding sequences as well as 5'- and 3'-flanking sequences of the Syrian hamster c-Ha-ras gene were deduced from cDNA clones derived from embryo fibroblast cell lines. Sequences of introns B, C, and D were obtained from genomic DNA after amplification by the polymerase chain reaction. Sequence comparisons with rat, mouse, and human c-Ha-ras genes revealed a high degree of homology. One of 12 cDNA clones contained intron-D-exon (IDX) sequences due to alternative splicing that would encode a p19 Ha-ras gene product. Conservation between species suggests a functional role for the IDX, possibly as a negative control of p21 Ha-ras expression.
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