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  • Title: Effects of artificial codon changes in the movement protein gene on adaptation of a hybrid bromovirus to cowpea.
    Author: Sasaki N, Kaido M, Okuno T, Mise K.
    Journal: Microbiol Immunol; 2004; 48(2):131-5. PubMed ID: 14978339.
    Abstract:
    A hybrid Cowpea chlorotic mottle virus(CCMV) with the movement protein (MP) gene replaced with that of the closely related Brome mosaic virus cannot infect cowpea systemically. Twenty-nine spontaneous mutants from the hybrid CCMV capable of systemic infection in cowpea appeared through biased codon changes that resulted in Lys or Arg at five specific positions in the MP gene. In this study, we report that systemic infection of cowpea with the hybrid CCMV can be achieved by artificial codon changes that do not result in Lys or Arg. We discuss mechanisms that restrict the occurrence of cowpea-adapted mutants in nature.
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