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  • Title: Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines.
    Author: Satyanarayana M, Tiwari P, Tripathi BK, Srivastava AK, Pratap R.
    Journal: Bioorg Med Chem; 2004 Mar 01; 12(5):883-9. PubMed ID: 14980600.
    Abstract:
    A series of aryloxypropanolamines (5a-r) of different chalcones (3a-e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models.
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