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  • Title: Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents.
    Author: Kumar PR, Raju S, Goud PS, Sailaja M, Sarma MR, Reddy GO, Kumar MP, Reddy VV, Suresh T, Hegde P.
    Journal: Bioorg Med Chem; 2004 Mar 01; 12(5):1221-30. PubMed ID: 14980634.
    Abstract:
    A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups.
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