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  • Title: Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.
    Author: Tandon VK, Chhor RB, Singh RV, Rai S, Yadav DB.
    Journal: Bioorg Med Chem Lett; 2004 Mar 08; 14(5):1079-83. PubMed ID: 14980639.
    Abstract:
    A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus.
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