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  • Title: Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!
    Author: Blizzard TA, Mosley RT, Birzin ET, Chan W, Hammond ML.
    Journal: Bioorg Med Chem Lett; 2004 Mar 08; 14(5):1317-21. PubMed ID: 14980690.
    Abstract:
    A series of 2-phenylspiroindenediones was prepared. The spiroindenediones were found to be less active than the corresponding spiroindenes as estrogen receptor ligands and failed to demonstrate the receptor subtype selectivity that had been anticipated from molecular modeling.
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