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  • Title: Clinical relevance of Hirschsprung-associated neuronal intestinal dysplasia (HANID).
    Author: Hanimann B, Inderbitzin D, Briner J, Sacher P.
    Journal: Eur J Pediatr Surg; 1992 Jun; 2(3):147-9. PubMed ID: 1498103.
    Abstract:
    The rate of Hirschsprung-associated neuronal intestinal dysplasia (HANID) is reported to be as high as 20-75% but no report deals with its sequelae. The aim of our study was to evaluate the influence of the retained neuronal dysplastic segment in patients with Hirschsprung's disease (HD). We report on 47 patients with HD including 11 cases with HANID (23%). All 47 children had a Duhamel procedure subsequent to colostomy and in none of the 11 cases with HANID was the neuronal dysplastic segment resected. There was no significant difference of early and late complications in both groups and the results of the mean follow-up of 5 years after the Duhamel procedure show that the patients with HANID did as well as the patients with isolated HD. It is suggested therefore that HANID may be a distinct disease compared to isolated NID and that the NID attained segment may be retained without increased risks or morbidity.
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