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  • Title: Serum parameters of iron metabolism in patients with breast cancer.
    Author: Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA.
    Journal: Anticancer Res; 2003; 23(6D):5107-9. PubMed ID: 14981974.
    Abstract:
    BACKGROUND: The aim of our study was to determine the incidence of anemia as evidenced by altered serum levels of iron metabolism in patients with breast cancer (n = 84), ductal carcinoma in situ (DCIS) (n = 29), fibroadenoma (n = 100) and healthy women (n = 14). MATERIALS AND METHODS: Hemoglobin (Hb), serum iron, serum ferritin, serum transferrin and serum transferrin receptor were evaluated prior to surgery. No patient with breast cancer had anemia according to Hb level. RESULTS: No significant correlations between serum iron, transferrin and transferrin receptor were ascertained. Serum ferritin was significantly elevated in patients with breast cancer. Among patients with breast cancer, a significant correlation with positive lymph node involvement was noted. CONCLUSION: Elevated serum ferritin might indicate the presence of malignant disease and could be regarded as a predictor of positive lymph node involvement in patients with breast cancer.
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