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  • Title: Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia.
    Author: Diwadkar VA, DeBellis MD, Sweeney JA, Pettegrew JW, Keshavan MS.
    Journal: Schizophr Res; 2004 Apr 01; 67(2-3):277-82. PubMed ID: 14984888.
    Abstract:
    The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
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