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  • Title: Vaginal metastasis and thrombocytopenia from renal cell carcinoma.
    Author: Allard JE, McBroom JW, Zahn CM, McLeod D, Maxwell GL.
    Journal: Gynecol Oncol; 2004 Mar; 92(3):970-3. PubMed ID: 14984968.
    Abstract:
    BACKGROUND: Vaginal cancer represents approximately 1-2% of genital tract malignancies. Most cases represent metastasis from the cervix, endometrium, or colon. Metastasis of renal cell carcinoma to the vagina is extremely rare. CASE: A 58-year-old female presented with a bleeding vaginal lesion. Laboratory studies revealed severe thrombocytopenia, and radiological studies revealed a left renal mass; excision was consistent with metastatic renal cell carcinoma. A subsequent nephrectomy confirmed renal cell carcinoma. Postoperatively, the patient underwent immunotherapy and the thrombocytopenia resolved. CONCLUSION: We report the first case of metastatic renal cell carcinoma presenting as a vaginal metastasis with thrombocytopenia as a paraneoplastic manifestation. Renal cell carcinoma must be in the differential diagnosis of a clear cell neoplasm in a postmenopausal woman, particularly with systemic symptoms suggestive of a paraneoplastic syndrome.
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