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  • Title: Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells.
    Author: Hisaoka K, Nishida A, Takebayashi M, Koda T, Yamawaki S, Nakata Y.
    Journal: Brain Res; 2004 Mar 26; 1002(1-2):167-70. PubMed ID: 14988048.
    Abstract:
    Antidepressants, which increase monoamine levels, induce glial cell line-derived neurotrophic factor (GDNF) release in C6 cells. Thus, we examined whether monoamines affect on GDNF release in C6 cells. We found that serotonin (5-HT) specifically increased GDNF mRNA expression and GDNF release in a dose- and time-dependent manner. The 5-HT-induced GDNF release was mediated through the MEK/mitogen-activated protein kinase (MAPK) pathway and, at least, 5-HT(2A) receptors. The action of 5-HT on GDNF release may provide important insights into the mechanism of antidepressants.
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