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  • Title: Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick.
    Author: Kabai P, Stewart MG, Tarcali J, Csillag A.
    Journal: Neurobiol Learn Mem; 2004 Mar; 81(2):155-8. PubMed ID: 14990236.
    Abstract:
    The avian lobus parolfactorius, equivalent to the medial striatum (caudate-putamen) of mammals, has been shown to be of crucial importance in passive avoidance training in day-old domestic chicks, where the aversive stimulus is the bitter tasting substance methylanthranilate. Here we report that the specific D1 antagonist SCH23390, injected into the lobus parolfactorius of day-old chicks (Gallus domesticus) prior to training, impaired performance on testing 30min post-training at low doses (0.5 and 25nmol). Sulpiride, a D2 antagonist, had no significant effect on performance in comparable doses. The early D1 activation may signify an essential mechanism leading to storage itself or to the canalisation of the relevant association to a permanent store.
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