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  • Title: (ADP-ribosyl)ation pattern of chromosomal proteins during ageing.
    Author: Mishra SK, Das BR.
    Journal: Cell Mol Biol; 1992 Jul; 38(4):457-62. PubMed ID: 1499045.
    Abstract:
    (ADP-ribosyl)ation of chromosomal proteins was studied by incubating the nuclei of brain and liver of young and old rats with 14C-NAD+. In brain as well as in liver histone proteins show approximately 2-3 fold higher (ADP-ribosyl)ation than that of non-histone chromosomal (NHC) proteins of both the age groups. H1 seems to be the major target for (ADP-ribosyl)ation. Amongst nucleosomal histones H2B is the main acceptor of 14C-labelled ADP-ribose moieties. A sharp age related decline of (ADP-ribosyl)ation of chromosomal proteins was observed in both the tissues.
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