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  • Title: Neurometabolic functioning and neuropsychological correlates in children with ADHD-H: preliminary findings.
    Author: Courvoisie H, Hooper SR, Fine C, Kwock L, Castillo M.
    Journal: J Neuropsychiatry Clin Neurosci; 2004; 16(1):63-9. PubMed ID: 14990761.
    Abstract:
    Proton magnetic resonance spectroscopy (MRS) and neuropsychological testing were conducted on 8 children with attention-deficit/hyperactivity disorder (ADHD-H), with no learning disabilities or comorbidities and 8 controls. Magnetic resonance spectroscopy revealed increased Glutamate/Glutamine in both frontal areas, and increased N-acetyl aspartate and Choline in the right frontal area of the ADHD-H subjects. Neuropsychological testing revealed few within- and between-group differences. Findings related to frontal lobe dysfunction in ADHD-H subjects were noted. N-acetylasparte/creatine (NAA/Creatine) in the right frontal region, and myoinositol/creatine (Myo inositol/Creatine) in the right and left frontal regions appear to be highly associated with the regulation of sensorimotor, language, and memory and learning functioning in children with ADHD-H.
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