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  • Title: Knockout mouse points to second form of tryptophan hydroxylase.
    Author: Veenstra-VanderWeele J, Cook EH.
    Journal: Mol Interv; 2003 Mar; 3(2):72-5, 50. PubMed ID: 14993427.
    Abstract:
    A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1(-/-) mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.
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