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  • Title: Golmaenone, a new diketopiperazine alkaloid from the marine-derived fungus Aspergillus sp.
    Author: Li Y, Li X, Kim SK, Kang JS, Choi HD, Rho JR, Son BW.
    Journal: Chem Pharm Bull (Tokyo); 2004 Mar; 52(3):375-6. PubMed ID: 14993767.
    Abstract:
    A new diketopiperazine alkaloid, golmaenone (1). and related alkaloids, neoechinulin A (2). and L-alanyl-L-tryptophan anhydride (3). have been isolated from the culture broth of the marine-derived fungus Aspergillus sp. The structure and absolute stereochemistry of the new compound (1). was assigned by spectroscopic methods and the advanced Marfey's method. Compounds 1 and 2 exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC(50) values of 20 and 24 microM, respectively, which are similar to the positive control, ascorbic acid (IC(50), 20 microM). Compounds 1 and 2 also showed an ultraviolet-A (UV-A) (320--390 nm) protecting activity with ED(50) values of 90 and 170 microM, respectively, which are more active than oxybenzone (ED(50), 350 microM) currently being used as sunscreen.
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