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  • Title: Use of magnetic nanoparticles as nanosensors to probe for molecular interactions.
    Author: Perez JM, Josephson L, Weissleder R.
    Journal: Chembiochem; 2004 Mar 05; 5(3):261-4. PubMed ID: 14997516.
    Abstract:
    Biocompatible magnetic nanosensors have been designed to detect molecular interactions in biological media. Upon target binding, these nanosensors cause changes in the spin-spin relaxation times of neighboring water molecules, which can be detected by magnetic resonance (NMR/MRI) techniques. These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5-30 fmol).
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