These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Arecoline tripeptide inhibitors of proteasome.
    Author: Marastoni M, Baldisserotto A, Canella A, Gavioli R, Risi CD, Pollini GP, Tomatis R.
    Journal: J Med Chem; 2004 Mar 11; 47(6):1587-90. PubMed ID: 14998343.
    Abstract:
    The 26S proteasome is a multicatalytic protease complex that plays an essential role in intracellular protein degradation. We have synthesized and tested a series of arecoline peptide derivatives where the peptide portion derives from a screening of tripeptide sequences, and the arecoline moiety has been considered as a potential substrate for catalytic threonine. Derivatives 17-19 are the best compounds of the series, showing chymotryptic-like (beta5) inhibition (IC(50) congruent with 1 microM) and favorable pharmacokinetic properties.
    [Abstract] [Full Text] [Related] [New Search]