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  • Title: Intraperitoneal cisplatin chemotherapy in ovarian carcinoma patients who are clinically in complete remission.
    Author: Menczer J, Ben-Baruch G, Rizel S, Brenner H.
    Journal: Gynecol Oncol; 1992 Aug; 46(2):222-5. PubMed ID: 1500025.
    Abstract:
    Three courses of intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection were administered to 31 stage II-IV ovarian carcinoma patients who were clinically in complete remission after completion of postoperative cisplatin-based combination chemotherapy. The 5-year survival rate was 60.4% and the median progression-free interval 35 months. Among 25 patients who underwent second-look laparotomy, the survival and the duration of the progression-free interval were significantly better in those with a pathologically confirmed complete response. Short-term intraperitoneal cisplatin chemotherapy should be considered for consolidation of treatment in ovarian carcinoma patients who are clinically in complete remission.
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