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  • Title: Monoclonal antibodies against metallothioneins from the human liver.
    Author: Van Houdt K, Nicasi I, Van Mechelen E, Veulemans B, De Ley M.
    Journal: Immunol Lett; 1992 Mar; 32(1):21-6. PubMed ID: 1500080.
    Abstract:
    Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern when tested with MTs from the livers of different mammals. A double-antibody sandwich enzyme-linked-immunosorbent-assay (ELISA) was developed with the antibodies L2E3 and L5G2. This assay allows the detection of 60 pg human fetal liver MT and exhibits a metal dependent response for Zn-, Cd- and Hg-MT.
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