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  • Title: The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection.
    Author: Wen WH, Chang MH, Hsu HY, Ni YH, Chen HL.
    Journal: J Pediatr; 2004 Mar; 144(3):397-9. PubMed ID: 15001956.
    Abstract:
    We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.
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