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  • Title: Relationship between dentifrice fluoride concentration and clinical caries reduction.
    Author: Tavss EA, Mellberg JR, Joziak M, Gambogi RJ, Fisher SW.
    Journal: Am J Dent; 2003 Dec; 16(6):369-74. PubMed ID: 15002949.
    Abstract:
    PURPOSE: To review the published literature on clinical caries trials of fluoride dentifrices and to combine their results in order to evaluate the correlation between fluoride concentration in dentifrice formulations and their anticaries efficacy, i.e., the dose-response relationship. METHODS: All available dentifrice caries clinical trials reported in the literature of products having at least two fluoride concentrations greater than 0 ppm were reviewed, graphed and statistically analyzed. RESULTS: The evaluation supported a linear correlation between the fluoride concentration of dentifrices between 0 and 5000 ppm F and clinical caries efficacy.
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