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  • Title: Determination of piroxicam and its major metabolites in the plasma, urine and bile of humans by high-performance liquid chromatography.
    Author: Milligan PA.
    Journal: J Chromatogr; 1992 Apr 15; 576(1):121-8. PubMed ID: 1500446.
    Abstract:
    A simple and sensitive liquid chromatographic method with ultraviolet detection is described for the determination of the nonsteroidal anti-inflammatory drug piroxicam and its major metabolites in human plasma, urine and bile. Separation of these components occurs on a reversed phase C10CN column with a mobile phase consisting of acetonitrile-water-sodium dihydrogenphosphate solution. The detection limit of the assay was 50 ng/ml with intra- and inter-assay coefficients of variation for piroxicam of the order of 2 and 5%, respectively. The assay linearity was good (typically r = 0.9999). This method can be readily utilised for clinical pharmacokinetic and mass-balance studies.
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