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  • Title: The significance of antisperm antibodies for sperm-cervical mucus interaction.
    Author: Kremer J, Jager S.
    Journal: Hum Reprod; 1992 Jul; 7(6):781-4. PubMed ID: 1500475.
    Abstract:
    An overview is presented of the effects of antisperm antibodies on the sperm-cervical mucus interaction. Antisperm IgA on spermatozoa or in cervical mucus can severely inhibit sperm penetration of cervical mucus and migration through it. Disturbance of the sperm-cervical mucus interaction is the only firmly established effect of these antisperm antibodies and leads to reduced fertility, as shown by a poor or negative result of the post-coital test. The presence of antisperm IgA in the male or female partner can be investigated more specifically with the sperm-cervical mucus contact test and can be confirmed by the sperm agglutination test on bromelinliquefied cervical mucus, by the mixed antiglobulin reaction test or by the immunobead test for IgA.
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